Epinephrine - Due to the possible for promethazine to reverse epinephrine’s vasopressor influence, epinephrine really should not be utilised to take care of hypotension connected with promethazine overdose.
Codeine has superior antitussive exercise, Despite the fact that fewer than that of morphine at equivalent doses. It's Employed in preference to morphine, since Uncomfortable side effects are infrequent at the same old antitussive dose of codeine.
A possibly fatal symptom elaborate from time to time called Neuroleptic Malignant Syndrome (NMS) has become noted in Affiliation with promethazine HCl by itself or in combination with antipsychotic medicine.
Pregnancy Exams: Diagnostic pregnancy assessments based on immunological reactions in between HCG and anti-HCG may bring about Phony-detrimental or Bogus-favourable interpretations.
Life-threatening respiratory depression and death have happened in little ones who received codeine; most circumstances adopted tonsillectomy and/or adenoidectomy, and lots of of the kids experienced evidence of getting an extremely-quick metabolizer of codeine as a consequence of a CYP2D6 polymorphism. (five.3) Promethazine HCl and Codeine Phosphate Oral Solution is contraindicated in little ones younger than 12 decades of age As well as in youngsters youthful than 18 years of age pursuing tonsillectomy and/or adenoidectomy.
Since recurrences of NMS have already been described with phenothiazines, the reintroduction of promethazine HCl must be thoroughly viewed as.
Because narcotic analgesics may possibly boost biliary tract force with resultant increases in plasma amylase or lipase stages, perseverance of such enzyme levels could be unreliable for twenty-four hrs following a narcotic analgesic has been provided.
Specific scientific studies to check the action with the drug on parturition, lactation, and growth on the animal neonate were not done, but a common preliminary analyze in rats indicated no impact on these parameters.
In another study one a hundred-mg/kg dose of codeine administered to pregnant mice reportedly resulted in delayed ossification from the offspring.
The subsequent laboratory tests can be impacted in people that are receiving therapy with check here promethazine HCl:
Serious breathing complications. Promethazine HCl Oral Answer shouldn't be Utilized in sufferers with bad lung perform for instance Persistent obstructive lung sickness or respiration challenges though sleeping (slumber apnea.)
Pediatric sufferers ought to be supervised to stay away from prospective damage in bike Using or in other hazardous pursuits.
Promethazine is really a phenothiazine by-product which differs structurally in the antipsychotic phenothiazines through the presence of a branched facet chain and no ring substitution.
The majority of scientific studies inspecting using promethazine in pregnancy did not uncover an association with a heightened risk of congenital anomalies. Within the couple studies reporting an Affiliation, no steady sample of malformations was famous.